鼻腔鼻窦内翻性乳头状瘤相关分子研究进展

Progress on molecular research of Inverted Sinonasal Papilloma of Nasal Cavity and Paranasal Sinuses

摘要:

鼻腔鼻窦内翻性乳头状瘤（ISP）是鼻腔鼻窦良性肿瘤的一种，首选的治疗方法是手术治疗，又因其局部侵袭样生长、复发倾向、恶变这3个特点而区别于良性肿瘤，故ISP初发的手术治疗及术后随访至关重要。目前ISP诊断、治疗、随访等主要依据为影像学、病理学及内镜技术，而因ISP发生机制尚不明确利用ISP分子生物学机制指导ISP的诊治极少，因此，研究ISP相关分子有助于探索影响ISP的关键基因，为ISP的诊治提供新的思路及有利证据。近年来国内外学者对一些因子在ISP中的表达方面做了大量的研究，本文系统地回顾了国内外相关文献，总结分析了已研究的ISP相关分子并予以综述。

Abstract:

Inverted sinonasal Papilloma (ISP) is a kind of benign tumors of the nasal and paranasal sinuses. The preferred treatment for ISP is surgical treatment, which is different from the benign tumors due to the three characteristics of local invasive growth, recurrence tendency and malignant transformation. Therefore, ISP’s initial surgical treatment and postoperative follow-up are very important.At present, the diagnosis, treatment and follow-up of ISP are mainly based on imaging, pathology and endoscopic technologies. However, due to the unclear mechanism of ISP occurrence, ISP molecular biological mechanism is rarely used to guide ISP diagnosis and treatment. Therefore, the study of ISP-related molecules is helpful to explore the key genes affecting ISP and provide new ideas and favorable evidence for the diagnosis and treatment of ISP.In recent years, scholars at home and abroad have done a lot of research on the expression of some factors in ISP. In this paper, the relevant literatures at home and abroad are systematically reviewed. This paper summarized and analyzed the research on ISP-related molecules.