血小板相关参数与突发性聋相关性分析

Correlation analysis of platelet parameters and sudden sensorineural hearing loss

摘要:

目的 探讨血小板相关参数中血小板计数（PLT）、血小板平均体积（MPV）、血小板/淋巴细胞比值（PLR）与不同类型突发性聋（SSNHL）发病的关系及对预后的影响。方法 121例SSNHL患者分为4组，其中低频下降型38例，高频下降型20例，平坦下降型31例，全聋型32例。同时根据疗效判定又将不同类型的SSNHL患者分别分为改善和未改善。并收集相同时期121例健康人作为对照组。比较SSNHL患者PLT、MPV、淋巴细胞绝对值、PLR与对照组的差异、不同类型SSNHL患者之间的差异及不同类型SSNHL患者治疗后改善与未改善患者之间的差异。结果 SSNHL患者与对照组间PLT、淋巴细胞绝对值、PLR比较，差异均具有统计学意义（P均<0.05）。不同类型SSNHL患者组间参数比较， PLR差异具有统计学意义（P<0.05）。不同类型SSNHL患者治疗改善与未改善参数比较，PLT、MPV、淋巴细胞绝对值、PLR差异均无统计学意义（P均>0.05）。结论 SSNHL患者PLT及PLR高于对照组，提示血小板在SSNHL的发病机制中起重要作用，炎症也可能是SSNHL发病的重要因素。但不同类型SSNHL的预后与PLT、MPV、PLR无关。

Abstract:

Objective To determine the correlations between the platelet parameters (platelet count，PLT;mean platelet volume, MPV;platelet-to-lymphocyte ratio, PLR) and the occurrence and prognosis of different types of sudden sensorineural hearing loss(SSNHL).Methods One hundred and twenty-one SSNHL patients were included. Of them, 38 were low-frequency descending type, 20 were high-frequency type, 31 were all-frequency type, and 32 total-deafness type. The patients with different types of SSNHL were then divided into improved subgroup and unimproved subgroup according to hearing level after treatment. Meanwhile, 121 healthy subjects were chosen as control. The differences of PLT, MPV, lymphocyte count and PLR between the patients and controls, and those among the patients with different types of SSNHL,as well as those between the improved and unimproved subgroups in different types of SSNHL were compared.Results The differences of PLT, lymphocyte count and PLR between the patients and controls were statistically significant (all P<0.05). The differences of PLR among the patients with different types of SSNHL were statistically significant(P<0.05) The differences of PLT, MPV, lymphocyte count and PLR between the improved and unimproved subgroups in different types of SSNHL were all statistically insignificant(all P>0.05).Conclusions The PLT and PLR of SSNHL patients are significantly higher than those of the controls, suggesting that platelet plays an important role in the pathogenesis of SSNHL, and inflammation may also be an important factor in the pathogenesis. However, PLT,MPV and PLR have no correlation with the prognosis of SSNHL.