Abstract:Objective To determine the correlations between the platelet parameters (platelet count，PLT;mean platelet volume, MPV;platelet-to-lymphocyte ratio, PLR) and the occurrence and prognosis of different types of sudden sensorineural hearing loss(SSNHL).Methods One hundred and twenty-one SSNHL patients were included. Of them, 38 were low-frequency descending type, 20 were high-frequency type, 31 were all-frequency type, and 32 total-deafness type. The patients with different types of SSNHL were then divided into improved subgroup and unimproved subgroup according to hearing level after treatment. Meanwhile, 121 healthy subjects were chosen as control. The differences of PLT, MPV, lymphocyte count and PLR between the patients and controls, and those among the patients with different types of SSNHL,as well as those between the improved and unimproved subgroups in different types of SSNHL were compared.Results The differences of PLT, lymphocyte count and PLR between the patients and controls were statistically significant (all P<0.05). The differences of PLR among the patients with different types of SSNHL were statistically significant(P<0.05) The differences of PLT, MPV, lymphocyte count and PLR between the improved and unimproved subgroups in different types of SSNHL were all statistically insignificant(all P>0.05).Conclusions The PLT and PLR of SSNHL patients are significantly higher than those of the controls, suggesting that platelet plays an important role in the pathogenesis of SSNHL, and inflammation may also be an important factor in the pathogenesis. However, PLT,MPV and PLR have no correlation with the prognosis of SSNHL.
