鼻内翻性乳头状瘤发生发展机制的研究进展

Advances in research on mechanism of development of nasal inverted papilloma

摘要:

鼻内翻性乳头状瘤（NIP）是鼻腔鼻窦相对较少见的良性肿瘤，随着人们对该疾病的认识和检测技术的发展，近年来其发病率呈上升趋势，因其具有易复发、易恶变、易局部侵犯等恶性肿瘤的特性而备受关注。目前认为NIP的发生及恶变与人乳头状瘤病毒（HPV）密切相关，NIP发生恶变的主要类型是鳞状细胞癌。而NIP复发的关键是手术路径、手术方式的选择以及肿瘤组织的残余。而且还认为因其侵犯骨质，在手术过程中未能完全清除有病变的骨质也是其可能复发的原因。NIP肿瘤组织基因表达的改变、免疫炎症微环境、周围环境中污染物均被认为是NIP的发生发展的易感因素。当前已经有很多对NIP的发生发展机制的研究，但缺乏系统、全面的总结报道。本文将系统性地进行文献回顾，对NIP的发生发展及作用机制进行总结与分析。

Abstract:

Nasal inverted papilloma (NIP) is a rare benign neoplasm of nasal cavity and sinus. However, its incidence has been on the rise in recent years with people's understanding of this disease and the development of detective technology. This disease gets a lot of attention for local recurrence, malignant transformation and local invasion. It is believed that the occurrence and malignant transformation of NIP are closely related to human papillomavirus (HPV). Currently, the main type of malignant transformation NIP is considered to be squamous cell carcinoma. In addition, the choices of surgical approach and residual tumor may also play the key role in the cause of NIP recurrence. What's more, because the operator can't totally removed the invasive bones also is the possible reason for recurrence. Other factors, such as the alteration of genic expression, inflammatory microenvironment and pollutants in the surroundings, also have the relationship with the progression of NIP. Although there are many papers to study the mechanism of NIP, but still lack of the systematic and comprehensive reporting. In this paper, a systematic review of the literature will be conducted to summarize and introduce the relevant factors of mechanism of NIP.