Abstract:Objective This paper reports a case of neonatal nasopharyngeal rhabdomyosarcoma (RMS) and reviews the related literature in order to improve the clinician awareness of the disease. Methods The patient, female, 16 days old, was found to have nasal obstruction and open-mouth breathing after birth, and suffocated and dyspnea when sucking. The examinations of Nasopharyngeal endoscopy, CT and MRI suggested space-occupying lesions in the nasopharynx. And the diagnosis of RMS was confirmed by postoperative pathological and immunohistochemical examination after biopsy. Results The patient's condition was improved after systemic chemotherapy. The endoscopy and imaging reexamination at the age of 8 months showed that the local lesions were smaller than before, and the general condition was good. No head, neck or systemic metastasis of the patient was observed. Conclusion RMS in neonatal nasopharynx is very rare, with hidden location and no typical clinical manifestations in early stage, which is easy to cause misdiagnosis and missed diagnosis. The malignant degree of this disease is high. Early detection, early diagnosis and early treatment of this disease should be tried to improve the survival rate of patients.
