Abstract:Objective To explore the method of repairing large perforation of nasal septum with auricular cartilage combined with pedicled nasal mucoperiosteal flap. Methods Eighteen patients with large nasal septum perforation (diameter ≥ 15 mm)in the 940 th Hospital of the Joint Logistics Support Force were selected,who were repaired with auricular cartilage combined with pedicled nasal mucoperiosteal flap under nasal endoscope, interrupted suture and gelatin sponge application. The survival of the repair was observed after operation. Results All the 18 patients were followed up for half a year to one year after the operation, and the graft repair was successful in 17 patients.All the grafts were survived after the reexamination half a year after the operation. One patient had a small residual perforation (diameter of 2 mm) at the time of reexamination half a year after surgery. The fresh wound was sutured again under nasal endoscope in outpatient department, and the wound healed completely after 2 months of dressing change. Conclusion using tragus cartilage combined with pedicled nasal mucoperiosteal flap to repair large perforation of nasal septum under nasal endoscope is an effective method, which can be popularized in clinical practice.