嗜酸性中耳炎的研究新进展

Research progress of eosinophilic otitis media

摘要:

嗜酸性中耳炎（EOM）其显著特点是中耳腔中的黏液中含有大量的嗜酸性粒细胞，常合并支气管哮喘或变应性鼻炎。传统的治疗中耳炎的方法，如：鼓膜切开、抗生素消炎、乳突根治术等并不能取得良好的效果。经过临床治疗发现，全身或局部运用类固醇类激素及生物靶向治疗，效果显示优于传统治疗。因嗜酸性中耳炎相对少见，临床表现并不典型，发现时已经是较严重阶段，患者常错过最佳的治疗时期。本文对嗜酸性中耳炎的发病机制、临床表现、临床分型、影像学特点、诊断标准及治疗进行综述，以期提高对嗜酸性中耳炎的认识。

关键词:嗜酸性中耳炎;嗜酸性粒细胞;激素

Abstract:

Eosinophilic otitis media (EOM) is characterized by a large amount of eosinophils in the mucus of the middle ear cavity, which is often associated with bronchial asthma or allergic rhinitis. Traditional methods of treating otitis media, such as tympanotomy, antibiotics anti-inflammatory, radical mastoidectomy, etc. can not achieve good results. Through clinical treatment, the effect of steroid hormones and biological targeted therapy systemically or locally is superior to that of traditional therapy. Eosinophilic otitis media is relatively rare and its clinical manifestations are not typical. Patients often miss the optimal treatment period when it is found in a relatively severe stage. This article reviews the pathogenesis, clinical manifestations, clinical classification, imaging features, diagnostic criteria and treatment of eosinophilic otitis media to improve the understanding of eosinophilic otitis media.

Key words:Eosinophilic Otitis Media;Eosinophils;Steroid