溶血磷脂酸在甲状腺癌中的作用

Research status of lysophosphatidic acid in thyroid carcinoma

摘要:

溶血磷脂酸（LPA）是磷脂生物合成中的重要前体以及细胞间的脂质信号分子，通过作用于其同源的G蛋白偶联受体发挥广泛的生物学效应。LPA可以调节细胞增殖、侵袭、粘附、血管生成，从而促进肿瘤生长和转移，并参与癌干细胞和肿瘤微环境的调节。LPA的产生、受体的表达和信号转导异常与甲状腺癌（TC）的发生、发展和转移有关。因此研究TC发病机制对于TC临床诊断和治疗都显得尤为必要。本文主要从LPA合成、代谢、失活；ATX-LPA信号轴的生物学功能以及其在TC中的作用进行综述。

Abstract:

Lysophosphatidic acid (LPA) is an important precursor in phospholipid biosynthesis and an intercellular lipid signaling molecule that exerts a wide range of biological effects by acting on its homologous G-protein-coupled receptors. LPA can regulate cell proliferation, invasion, adhesion and angiogenesis, thus promote tumor growth and metastasis, and is involved in the regulation of cancer stem cells and tumor microenvironment. The abnormalities of LPA production, receptor expression and signal transduction are related to the occurrence, development and metastasis of thyroid carcinoma (TC). It is particularly necessary to study the pathogenesis of TC for clinical diagnosis and treatment. This paper mainly focuses on LPA synthesis, metabolism and inactivation, and reviews the biological function of autotaxin-LPA signal axis and its role in TC.