质金属蛋白酶及抑制剂影响细胞外基质代谢参与慢性鼻-鼻窦炎组织重塑的机制研究

Advances in the mechanism of matrix metalloproteinases and inhibitors affecting extracellular matrix metabolism and participating in CRS tissue remodeling

摘要:

目的组织重塑是慢性鼻鼻窦炎（CRS）发病机制的主要因素，细胞外基质(ECM)生成与降解紊乱是组织重塑的重要特征。在两种不同表型CRS伴息肉（CRSwNP）和不伴息肉（CRSsNP）中，组织重塑所涉及的病理生理机制并不相同。基质金属蛋白酶（MMPs）可降解ECM大部分成分，其与内源性组织金属蛋白酶抑制剂（TIMPs）的平衡是ECM代谢的主要决定因素,二者的比例失衡将通过影响ECM代谢参与CRS组织重塑过程，促进CRS疾病进展，为CRS预后评估及药物治疗靶点提供理论基础。

关键词:慢性鼻-鼻窦炎|基质金属蛋白酶|组织重塑|细胞外基质

Abstract:

ObjectiveTissue remodeling is a major factor in the pathogenesis of CRS (Chronic Rhinosinusitis, CRS), The generation and degradation disorder of extracellular matrix (ECM) is an important feature of CRS tissue remodeling. The pathophysiological mechanisms involved in tissue remodeling were different between the two phenotypic CRS with and without polyps (CRSwNP) and CRSsNP. Matrix metalloproteinases (MMPs) can degrade most components of ECM. MMPs. And the balance between MMPs and TIMPs (tissue metalloproteinase inhibitors,TIMPs)of endogenous inhibitors is a major determinant of ECM metabolism. Their imbalance will be involved in the mechanism of CRS tissue remodeling by influencing ECM metabolism, which will promote the progression of CRS disease. It will provide a theoretical basis for CRS prognosis evaluation and drug therapeutic targets.

Key words:CRS|MMPs|Tissue remodeling| Extracellular matrix