益生菌辅助治疗变应性鼻炎疗效的Meta分析

Efficacy of Probiotics in the treatment of allergic rhinitis：a Metaanalysis

摘要:

目的通过Meta分析对益生菌辅助治疗变应性鼻炎（AR）的临床疗效进行评价。方法系统检索知网、万方、PubMed数据库，检索发表自2010年1月—2019年12月使用益生菌治疗AR的文献，按照纳入及排除标准筛选并提取数据资料、行质量评价。采用RevMan 5.2软件进行Meta分析。结果最终纳入随机对照试验13例，共1 268例患者，其中常规治疗+益生菌组631例，常规治疗+安慰剂或仅常规治疗组637例。Meta分析结果显示：常规治疗+益生菌组治疗后鼻部症状评分较常规治疗+安慰剂或仅常规治疗组降低，差异具有统计学意义（MD=-1.84，95％CI=［-2.43，-1.24］，P<0.05）。两组治疗AR有效率存在差异，但差异无统计学意义（RR=1.36，95％CI=［1.00，1.85］，P=0.05）。结论常规治疗+益生菌组与常规治疗+安慰剂或仅常规治疗组比，治疗后AR鼻部症状评分下降；两组治疗总有效率差异无统计学意义。

关键词:变应性鼻炎|益生菌|Meta分析

Abstract:

ObjectiveThe clinical efficacy of probiotics in the treatment of allergic rhinitis (AR) was evaluated by Meta analysis.MethodsLiteratures about the effect of probiotics on AR were searched in PubMed, CNKI and WanFang Data from Jan 2010 to Dec 2019. The quality of the screened literature and the extracted data was evaluated according to a criteria of inclusion and exclusion. Then Metaanalysis was performed using RevMan 5.2 software．ResultsA total of 13 Randomized controlled trials(RCTs) involving in 1 268 patients were included in the Metaanalysis. There were 631 cases in the regular treatment and probiotic group, and 637 cases in the regular treatment and placebo or only regular treatment group．The results of Metaanalysis showed that the nasal symptom score reduced significantly between the two groups, and more reduction in the regular treatment and probiotic group（MD=-1.84，95％CI=［-2.43，-1.24］，P<0.05）. There was a difference in the effective rate of AR treatment between the two groups, but the difference was not statistically significant（RR=1.36，95％CI=［1.00，1.85］，P=0.05）.ConclusionsThe nasal symptom score of AR decreased after treatment in the regular treatment and probiotic group, which was compared to the regular treatment and placebo or only regular treatment group. And there was no statistically significant difference in the total effective rate between the two groups.

Key words:Allergic rhinitis|Probiotic| Metaanalysis