Abstract:ObjectiveTo investigate the clinical diagnosis and treatment of papillary thyroid carcinoma (PTC) with cervical Unicentric Castleman diease (UCD).MethodsA retrospective analysis was performed on the clinical data of 1 case of PTC with cervical UCD. Then, we searched domestic and foreign literature, and summarized the main points of clinical diagnosis and treatment.The patient underwent preoperative thyroid nodule biopsy cytology (FNA) for PTC with lymph node enlargement in the right cervical region, which was underwent the right thyroid gland lobules and isthmic resection and dissection of lymph node II, III, IV and VI in the right cervical region.ResultsThe patient was cured and discharged 4 days after the operation, his wound healed well without symptoms of hoarseness or hypocalcemia postoperative,and no recurrence by followed up for 6 months. Postoperative pathology confirmed that the enlarged lymph nodes in the lateral cervical region for UCDs.ConclusionPTC combined with UCD was extremely rare, and preoperative diagnosis of UCD was difficult.But surgical removal can often cure the disease. For patients with PTC combined with cervical enlarged lymph nodes, clinicians should not only consider the possibility of thyroid cancer metastatic lymph nodes, but also be alert to the presence of UCD.