HMGB1在鼻黏膜及下气道炎性疾病中的作用及其研究进展

The role of HMGB1 and its research progress in inflammatory diseases of nasal mucosa and lower airway

摘要:

摘要：目的高迁移率族蛋白B1（HMGB1）是一种促炎性细胞因子，在生物体各细胞中广泛表达,可与晚期糖基化受体或Toll样受体结合，促进炎性因子分泌。研究表明,HMGB1呼吸道炎性相关疾病的发生发展密切相关,在疾病的诊断、预后评估等方面发挥着重要的作用。本文主要从HMGB1作用途径及其与鼻黏膜炎性疾病及下气道炎症性疾病发生发展的关系这两方面进行综述，以期为呼吸道慢性疾病的防治提供一定的启示。

关键词:慢性鼻-鼻窦炎|变应性鼻炎|支气管哮喘|高迁移率族蛋白B1(HMGB1)|气道炎症

Abstract:

ObjectiveHigh mobility group protein B1 (HMGB1) is a proinflammatory cytokine, which is widely expressed in various cells of an organism, which can be combined with receptors of advanced glycation end products (RAGE) or tolllike receptors to promote the secretion of inflammatory cytokines.Studies have shown that HMGB1 is closely related to the occurrence and development of respiratory inflammatory diseases. HMGB1 plays an important role in the diagnosis and prognosis evaluation of diseases.In this paper, we reviewed the pathway of HMGB1 and its relationship with the occurrence and development of nasal mucosa inflammatory disease and lower airway inflammatory disease.MethodsResultsConclusion

Key words:Chronic rhinosinusitis| Allergic rhinitis|Bronchial asthma| High mobility group protein B1(HMGB1)| Airway inflammation