Abstract:ObjectiveTo evaluate the clinical effect of tansnasal endoscopic eustachian tube insufflation and simultaneous drug injection combined with oral administration for the treatment of acute secretory otitis media (ASOM).MethodsA total of 135 outpatients with ASOM from Aug 2018 to Oct 2019 were selected. They were randomly allocated to control group (42 patients, 50 ears),routine group (45 patients, 53 ears) and research group (48 patients, 55 ears). The patients in the research group were given tansnasal endoscopic eustachian tube insufflation and simultaneous drug injection combined with oral administration, those in the routine group were given auripuncture combined with oral administration, while those in the control group were given oral administration only. Two months after treatment, the clinical effect, changes of tympanogram, average airconducted puretone auditory thresholds, complications and adverse events, recurrence rates among the three groups were observed and compared.ResultsResults The differences of total effective rate among the three groups were statistically significant (all P<0.05), while those of recurrence rates were statistically insignificant (all P>0.05).ConclusionWith advantages of definite clinical effect, good safety, less complications and high patient acceptance, transnasal endoscopic eustachian tube insufflation and simultaneous drug injection combined with oral administration is worthy of clinical promotion for the treatment of ASOM.