Abstract:Abstract:ObjectiveTo explore the application of endonasal endoscopic surgery for pediatric skull base tumors.MethodsClinical data of 44 pediatric patients who received endoscopic endonasal skull base surgery for skull base tumors between June 2010 and Nov 2019 were analyzed retrospectively. The tumors included juvenile nasopharyngeal angiofibroma (JNA)(n=17), Langerhans histiocytosis (LCH) (n=7), ossifying fibroma (n=5), primitive neuroectodermal tumor (PNET) (n=2), rhabdomyosarcoma (n=2), meningioma (n=2), cartilage mesenchymal hamartoma (n=1), craniopharyngioma (n=1), epidermoid cyst (n=1), angiolipoma (n=1), germ cell tumor (GCT) (n=1), osteoblastoma (n=1), chordoma (n=1), invasive pituitary adenoma (IPA) (n=1), and fibromatosis (n=1).ResultsEndoscopic complete tumor resection was achieved in 43 children, and resection of JNA was performed in three stages in one case. All the 44 cases were followed up for 3 months to 9 years postoperatively. Among them, 5 cases were lost to follow up, including 1 with osteoblastoma, 1 with meningioma, 1 with rhabdomyosarcoma, 2 with JNA. Except for the 5 patients lost to followup, 12 cases (7 with LCH, 2 with PNET, 1 with rhabdomyosarcoma, 1 with chordoma and 1 case with GCT) received postoperative radiotherapy and chemotherapy, and they were all in good condition with neither recurrence nor metastasis during followup period.One patient had recurrence of JNA, which was cured after reoperation. No recurrence was found in the rest 26 cases.ConclusionEndonasal endoscopic skull base surgery is feasible, effective, and safe for pediatric skull base tumor.
