ObjectiveTo analyze the clinical features and treatment of primary laryngeal amyloidosis.MethodsClinical data of 4 patients with primary laryngeal amyloidosis surgically treated in our hospital between April 2017 and Jan 2019 were analyzed retrospectively, and relevant literatures were reviewed.ResultsComplete surgical removal of lesion was achieved in all the patients without laryngotracheal dysfunction. Of them, mass resection was performed via middle laryngeal fissure in 2 cases, CO2 laser removal under selfretaining laryngoscope in the other two. Postoperative pathological results confirmed the diagnosis of amyloidosis. No clinical and experimental evidences indicated systemic amyloidosis. Postoperative followup for 3 months to 2 years revealed no recurrence.ConclusionIsolated laryngeal amyloidosis is a rare benign tumor that should be differentiated from other benign and malignant laryngeal tumors. Systemic amyloidosis should be excluded before treatment. The main treatment strategy is surgery and should be conservative to preserve organ function.
