慢性鼻窦炎动物模型应用现状及评价指标

Application status and evaluating indexes of animal models of chronic sinusitis

摘要:

目的慢性鼻窦炎（chrohic rhinosinusitis,CRS）是上呼吸道常见的慢性炎症性疾病，已经成为严重影响公众健康的慢性疾病之一,根据目前国内外指南的治疗方法难以根治，主要原因是该疾病病因复杂呈异质性、发病机制尚不完全清楚，而基础研究缺乏成熟稳定的动物模型是重要原因。目前建立的CRS动物模型还存在各种争议，未形成成熟稳定公认的动物模型。本文就近十年来国内外建立CRS动物模型的现状进行简要综述，分析各种动物模型的优缺点，以期对未来研究CRS选择正确的模型起指导作用。

Abstract:

Abstract:ObjectiveChronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which has become one of the chronic diseases seriously affecting public health. According to the current domestic and international guidelines, it is difficult to cure it. The main reason is that the etiology of CRS is complex and heterogeneous, and the pathogenesis is not completely clear. The lack of mature and stable animal models in basic research is an important reason. At present, the established animal model of CRS is still controversial, and has not formed a mature and stable animal model. In this paper, the current situation of establishing animal models of CRS at home and abroad in the recent ten years is briefly reviewed, and the advantages and disadvantages of various animal models are analyzed in order to guide the selection of correct CRS models in future studies.