嗜酸性粒细胞浸润程度与鼻息肉术后疗效的相关性分析

Correlation analysis of the degree of eosinophil infiltration in nasal polyps and the curative effect of surgical treatment

摘要:

目的探讨嗜酸性粒细胞在鼻息肉中的浸润程度与术后疗效的关系。方法收集眉山市人民医院2014~2017年接受手术治疗的124例鼻息肉（包括Ⅱ、Ⅲ型）患者为研究对象，术后对鼻息肉中嗜酸性粒细胞浸润程度与疗效进行分析。结果术后随访6个月，Ⅱ型1期有效率为100.00％，Ⅱ型2期有效率为88.00％，Ⅱ型3期有效率为100.00％，Ⅲ型有效率为82.61％，Ⅱ型1期和3期有效率均高于Ⅱ2期和Ⅲ型 ，Ⅱ型2期有效率高于Ⅲ型 ，但各组比较差异均无统计学意义（P>0.05）；Ⅰ度嗜酸性粒细胞浸润的鼻息肉手术有效率为100.00％，Ⅱ度有效率为96.43％，Ⅲ度有效率为75.00％， Ⅳ度有效率为0.00％,Ⅰ度有效率均高于Ⅱ、Ⅲ和Ⅳ度（χ2=4.009、11.786、52.000，P<0.05），Ⅱ、Ⅲ度手术有效率高于Ⅳ度（χ2=19.371、12.000，P<0.05），Ⅱ与Ⅲ度比较差异无统计学意义（χ2=3.292，P>0.05）；Spearman相关性分析显示，嗜酸性粒细胞浸润程度与术后疗效呈负相关（P<0.05）。结论嗜酸性粒细胞浸润程度与鼻息肉术后疗效相关，嗜酸性粒细胞浸润程度与鼻息肉术后疗效有关，嗜酸性粒细胞浸润程度越深，鼻息肉术后疗效越差，手术联合白三烯受体拮抗剂与鼻喷激素，对难治性慢性鼻-鼻窦炎伴鼻息肉患者有较好的治疗效果。

Abstract:

Abstract:ObjectiveTo investigate the relationship between the degree of eosinophil infiltration in nasal polyps and the curative effect of surgical treatment.Methods124 patients with nasal polyps (including II and III) who underwent surgical treatment in Meishan People’s Hospital from 2014 to 2017 were collected as the research object. The degree of eosinophil infiltration in nasal polyps and the curative effect were analyzed after operation.ResultsAfter 6 months of followup, the effective rate of II type 1 was 100.00%, that of II type 2 was 88.00%, that of II type 3 was 100.00%, and that of Ⅲ type was 82.61%. The effective rate of II type 1,3 was higher than that of II type 2 and Ⅲ; the effective rate of II type 2 was higher than that of Ⅲ; However, there was no significant difference between the groups (P>0.05). The effective rate of grade I in eosinophil infiltration of nasal polyps was 100.00%,and that of grade II was 96. 43%, that of grade III was 75.00%, and that of grade IV was 00.00%. The effective rate of grade Ⅰwas higher than that of gradeⅡ, Ⅲ and Ⅳ (χ2=4.009、11.786、52.000，P<0.05); The effective rate of grade Ⅱ, Ⅲwas higher than that of grade Ⅳ (χ2=19.371、12.000，P<0.05); The effective rate of grade Ⅱwas not different than that of grade Ⅲ (χ2=3.292，P>0.05). Spearman correlation analysis showed that the degree of eosinophil infiltration was negatively correlated with the postoperative outcome (P<0.05).ConclusionsThe degree of eosinophil infiltration is related to the curative effect of nasal polyps surgery. The deeper the infiltration of eosinophils, the worse the postoperative efficacy of nasal polyps. Surgery combined with leukotriene receptor antagonist and nasal spray hormone has a good therapeutic effect on the patients with refractory chronic rhinosinusitis with nasal polyps.