Abstract:Abstract:ObjectiveTo evaluate the onset time of sublingual immunotherapy (SLIT) and the objective index changes in children with allergic rhinitis (AR) in different age groups.MethodsCase data of 282 children with AR who underwent 2year SLIT with Dermatophagoides fannae drops were analyzed. All children with moderate to severe house dust mitesinduced AR were divided into three groups according to the age (aged 2~5 years, n=83; aged 6~9 years, n=102; aged 10~13 years, n=97) and treated by SLIT with Dermatophagoides fannae drops and symptomatic drugs. Their total nasal symptom score (TNSS), total medication score (TMS), visual analogue scale (VAS) score, and eosinophil (EOS) level at baseline, 3 months, 6 months, 12 months, and 24 months of treatment were recorded.Results①Compared with the baseline, the TNSS, TMS and VAS got reduced in all 3 groups at 3 months of SLIT, and the differences were statistically significant (all P<0.05)，but the differences between VAS at 3 and 6 months of SLIT were statistically insignificant (P>0.05).②The differences of TNSS and VAS at 3 months of SLIT between the 2~5 year old group and the 10~13 year old group were statistically significant (both P<0.05).③Compared with the baseline, the EOS decreased significantly after treatment for half a year of SLIT (all P<0.05).ConclusionsThe onset of action of SLIT with Dermatophagoides fannae drops can be observed at 3 months of treatment in children of all age groups, and that in the older group is more rapid than the younger group. In order to promote and consolidate the curative effect, it is necessary to strengthen the education and management during the 3rd to 12th month of treatment. The change of EOS has a certain correlation with immunotherapy.
