Abstract:ObjectiveTo investigate the clinical characteristics of sex hormones level in perimenopausal women with sudden hearing loss.MethodsBetween Aug. 2013 to Dec. 2017,132 patients with sudden deafness in perimenopausal period were enrolled in the Third Hospital of Shijiazhuang City as the research group,and another 129 perimenopausal healthy women as the control group.The levels of follicle stimulating hormone (FSH) , luteinizing hormone(LH), erum estradiol(E2), progesterone(P) and prolactin (PRL) of the study group were compared to those of the control group respectively. Then the differences of sex hormones level were analyzed in different degrees of hearing loss in perimenopausal group. Finally the correlation between sex hormones level and pure tone threshold was analyzed. SPSS 19.0 statistical software was used to analyze the data.ResultsThe decreased proportion of E2(89%) and P(68%)were higher significantly in the research group than those in the control group(67% and 52%),and the mean level of E2 and P（34.04±30.49) pmol/L and (0.61±0.37 ) nmol/L in the research group was significantly lower than those in the control group（62.03±30.32) pmol/L and (l.08±0.58) nmol/L(P<0.05).The levels of FSH, LH,T and PRL were not significantly different in the research group than those in the control group, P>0.05. E2 and P are significant differencein the different degrees of hearing loss. By analysis of correlation, the levels of E2 and P were negatively correlated with pure auditory threshold (P<0.05).ConclusionsThe levels of E2 and P decreased significantly in perimenopausal women with sudden hearing loss, which were negatively correlated with the severity of the disease. The clinical E2 and P may provide referential value for prevention、diagnosis and treatment of perimenopausal women with sudden hearing loss.
