Abstract:ObjectiveTo explore the diagnostic value of video nystagmography(VNG) for vestibular function in patients with sudden deafness and vertigo.Methods500 patients with sudden deafness hospitalized in our department between Feb. 2013 and Dec. 2017 were divided into vertigo group (n=180) and nonvertigo group (n=320). Pure tone audiometry and VNG were performed to all the patients. The results of both groups were compared. Meanwhile, the case numbers of flattype hearing loss, total hearing loss, lowfrequency loss, medialfrequency loss and highfrequency loss according to the audiogram were counted, and their vestibular functions were evaluated via caloric test. All the results were compared. The patients received corresponding treatment according to the results of VNG and correlative examinations, and the therapeutic effect of the two groups was compared.Results①The proportion of patients with normal vestibular function in vertigo group (48.9%) was significantly lower than that in nonvertigo group (83.8%)(P<0.05). The proportion of patients with severe hearing loss in vertigo group (67.2%) was significantly higher than that in nonvertigo group (28.1%)(P<0.05), and the proportion of patients with mild hearing loss (8.3%) was significantly lower than that in nonvertigo group (40.0%)(P<0.05). ②Pure tone audiometry revealed flattype hearing loss in 108 cases including 15 (13.9%) with abnormal vestibular function, total hearing loss in 78 cases including 34 (43.6%) with abnormal vestibular function, lowfrequency loss in 100 cases with abnormal vestibular function in 28 (28%), medialfrequency loss in 94 cases with abnormal vestibular function in 25 (26.6%), and highfrequency loss in 120 including 42 (35.0%) with abnormal vestibular function. The results showed that the rate of vestibular dysfunction in the patients with total deafness curve was significantly higher than those with other types of hearing curves. The caloric test showed that vestibular dysfunction was mainly displayed by hemispheric canal paralysis. ③The marked effective, effective and total effective rates of the vertigo group were 26.7%(48/180), 28.9%(52/180) and 55.6% (100/180) respectively, which were all significantly lower than those of the nonvertigo group (38.1%, 45.6% and 83.7%)(all P<0.05).ConclusionObviously damaged vestibular function presents in sudden deafness patients with vertigo. The vestibular function detection by VNG is of great significance to the evaluation, diagnosis and treatment of sudden deafness and vertigo, and worthy of clinical reference.