Abstract:ObjectiveTo discuss clinical manifestations, pathological features, treatment and prognosis of middle ear carcinoid tumor.MethodsClinical data of two patients suffering from middle ear carcinoid tumor diagnosed and treated in our hospital since 2011 were analyzed retrospectively with review of 25 cases reported in literatures published in Chinese between 2000 and 2018.ResultsThe most common clinical feature of this disease was hearing loss, followed by external auditory canal neoplasma and tinnitus. Among the 27 cases, immunohistochemistry was used to detect tumor markers in 15. The common markers associated with this disease were synaptophysin (Syn), chromogranin A (CgA), cytokeratin (CK), neuronspecific enolase (NSE), nerve cell adhesion molecule CD56 and vimentin. All the patients received surgical treatment, and followed up with an average duration of 25 months. Tumor recurrence occurred in 7.ConclusionMiddle ear carcinoid is a kind of middle ear tumor with low incidence, lack of specificity in clinical manifestations and imaging characteristics, and tendency to be missed and misdiagnosed. In clinical work, preoperative puncture biopsy or intraoperative frozen biopsy should be considered for middle ear mass with nonspecific clinical symptoms and imaging manifestations to determine the nature of the mass in order to protocol operative plan, so as to make the surgical method more reasonable and improve the prognosis. Although the prognosis of middle ear carcinoid is good, longterm followup should be adopted due to its inclination of late recurrence.
