嗜酸性粒细胞与慢性鼻-鼻窦炎伴鼻息肉的相关性研究进展

Research progress in the relationship between eosinophils and chronic rhinosinusitis with nasal polyps

摘要:

慢性鼻窦炎（chronic rhinosinusitis,CRS）是鼻腔黏膜和鼻窦黏膜的慢性炎性疾病，根据有无鼻息肉可分为慢性鼻-鼻窦炎伴鼻息肉（chronic rhinosinusitis with nasal polyps,CRSwNP）和慢性鼻-鼻窦炎（chronic rhinosinusitis without nasal polyps,CRSsNP）。鼻息肉组织常见有嗜酸性粒细胞(eosinophils，EOS) 浸润增多，根据嗜酸性粒细胞的浸润程度可将CRSwNP分为两个亚型：嗜酸粒细胞型慢性鼻窦炎伴鼻息肉(eosinophilic chronic rhinosinusitis with nasal polyps， ECRSwNP)和非嗜酸粒细胞型慢性鼻窦炎伴鼻息肉 (nonesinophilc chronic rhinosinusitis with nasal polyps，nonECRSwNP)；将慢性鼻窦炎分为：嗜酸粒细胞型慢性鼻窦炎（eosinophilic chronic rhinosinusitis， ECRS)和非嗜酸粒细胞型慢性鼻窦炎(noneosinophilic，NECRS)。嗜酸性粒细胞在鼻息肉形成、发展机制中的作用多年来一直备受学者们关注。随着研究的不断深入，嗜酸性粒细胞在鼻窦炎鼻息肉炎症趋化、息肉形成、分型和预后中的作用得到越来越多的重视。

关键词:鼻息肉|嗜酸性粒细胞|嗜酸粒细胞型慢性鼻窦炎伴鼻息肉

Abstract:

Chronic rhinosinusitis (CRS) is the chronic inflammatory mucosa disease of the nasal cavity and sinus. According to the presence or absence of nasal polyps, it can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Eosinophils (EOS) infiltration is common in nasal polyps. According to the degree of eosinophil infiltration, CRSwNP can be divided into two subtypes: eosinophilic CRSwNP (ECRSwNP) and nonesicophilic CRSwNP (nonECRSwNP). On this account, CRS can be divided into eosinophilic (eosinophilic CRS, ECRS) and noneosinophilic (NECRS). The role of eosinophils in process of recurrence and development of nasal polyps has been highly concerned for many years. Along with the thorough research, close attention has been paid to the roles of eosinophils in the chemotaxis, polypus formation, classification and prognosis of CRSwNP.

Key words:Nasal polyp|Eosinophil| Eosinophilic chronic rhinosinusitis with nasal polyps