Abstract:Abstract:ObjectiveTo explore the application of carbon nanoparticles suspension in improving the accuracy of thyroid papillary carcinoma surgery.MethodsClinical data of 98 patients with cN0 thyroid papillary carcinoma surgically treated in our department from June 2016 to June 2017 were analyzed retrospectively. All the patients were randomly divided into experimental group(n=50) and control group(n=48). The meticulous capsular dissection technique was adopted for both groups with intraoperative subcapsular injection of carbon nanoparticles suspension in the experimental group. The intraoperative exposure and incidental resection of parathyroid, recurrent laryngeal nerve injury as well as serum levels of calcium and parathyroid hormne (PTH) 24 hours after operation were compared between the two groups.Results111 parathyroid glands were founded in the experimental group and 93 in the control group (P<0.05). Incidental parathyroidectomy occurred in 2 cases (4%, 2/50) of the experimental group and 9 (18.75%, 9/48) of the control group (P<0.05). The incidences of temporary PTH reduction and hypocalcemia were 4% (2/50) and 6% (3/50) respectively in the experimental group, and those in the control group were 22.9% (11/48) and 27.1% (13/48), their differences between the two groups were statistically significant(both P<0.05). Temporal recurrent laryngeal nerve injury occurred in 3 case s(6%) of the experimental group and 10 (20.83%) of the control group (P<0.05).ConclusionIntraoperative subcapsular injection of carbon nanoparticles suspension can significantly improve the identification of parathyroid gland during thyroid cancer surgery and improve the recognition of recurrent laryngeal nerve to a certain degree.
