Abstract:ObjectiveTo investigate the clinical effect of endoscopic myringoplasty with biological amniotic membrane for treatment of tympanic membrane perforation.Methods38 patients suffering from tympanic membrane perforation repaired endoscopically with biological amniotic membrane in our hospital from April 2015 to March 2017 were included. The clinical data statistically analyzed included operation time, blood loss, healing of tympanic membrane perforation in 3 months and 6 months after myringoplasty, as well as hearing in 6 months postoperatively.ResultsThe healing rates of tympanic membrane perforation in 3 months and 6 months after surgery were 94.7%（36/38）and 92.1%（35/38）respectively. Postoperative pure tone audiometry revealed that their average air conduction threshold was (28.42±7.31)dB, which was increased by (17.19±5.31）dB compared with the preoperative one. The difference between preoperative and postoperative average air conduction threshold was statistically significant (P<0.05).ConclusionWith advantages of short operation time, less bleeding, avoidance of surgical incision and scar, endoscopic myringoplasty with biological amniotic membrane is a minimally invasive, safe and effective, economic method for the treatment of tympanic membrane perforation, which is worthy of clinical promotion and application.
