Abstract: ObjectiveTo introduce a novel method to reconstruct the posterior wall defect of frontal sinus by pedicle mucosal flap of nasal lateral wall with anterior ethmoidal artery, and to summarize the therapeutic effect as well as our preliminary application experiences.MethodsA retrospective study was conducted on 15 patients who underwent endoscopic treatment of cerebrospinal fluid (CSF) rhinorrhea from the posterior wall of frontal sinus. A total of 12 males and 3 females were included, aging from 12 to 51 years old, with a mean age of 32 years. The skull base defects of all patients were caused by trauma, and the expectant treatment for at least 1 month turned out to be ineffective. All patients underwent endoscopic skull base reconstruction through Draf IIB frontal sinusotomy combined with pedicle mucosal flap of nasal lateral wall with anterior ethmoidal artery.ResultsSuccessful onetime skull base reconstruction was achieved in all patients. Nasal stuffing was removed 1 month after surgery, and no CSF rhinorrhea occurred. All patients were followed up for 1 to 3 years, and neither recurrence of CSF rhinorrhea nor intracranial infection was observed. Both frontal sinus and maxillary sinus possessed unobstructed drainage as well as satisfactory epithelization with mycteroxerosis as the main side effect.ConclusionWith advantages of convenience in acquisition and satisfactory therapeutic effect, Draf IIB frontal sinusotomy combined with pedicle mucosal flap of nasal lateral wall with anterior ethmoidal artery is an innovative surgical technique to reconstruct the posterior wall defect of frontal sinus.