Abstract: ObjectiveTo investigate and summarize the clinical microsurgical skills of giant sphenoidalsellar region meningioma encapsulating internal carotid artery so as to improve the therapeutic effect. MethodsClinical data of 19 patients who underwent removal of giant sphenoidalsellar region meningioma encapsulating internal carotid artery in our department from May 2008 to May 2016 were analyzed retrospectively. Of them, 7 were male and 12 were female, with an age range of 34 to 68 years (average age 56.5 years) and disease duration ranged from 11 months to 6 years. Tumor resection was performed in all 19 patients via frontaltemporal approach.ResultsSimpson GradeⅡresection was achieved in 15 cases and Simpson grade Ⅲ resection in 4 with no deaths. All the patients had been followedup postoperatively for 2 to 8 years with an average of 6.5 years. No tumor recurrence occurred. In 6 patients, recoverable cerebral infarction occurred and got improved or disappeared within three months after operation. However, 3 cases with unrecoverable cerebral infarction had no improvement one year after the operation.ConclusionWith significant risks, prejudgement of the important anatomical structures at the skull base, sharp separation along neurovascular course, avoidance of intraoperative rupture of internal carotid artery and prevention of postoperative vasospasm are essential for good therapeutic effect in the surgical treatment of giant sphenoidalsellar region meningioma encapsulating internal carotid artery.