Abstract: ObjectiveTo investigate the microsurgical technique and outcome of midline anterior cranial fossa meningiomas via transorbitalfrontal sinus approach.MethodsClinical data of 6 patients with midline anterior cranial fossa meningiomas, who underwent tumor resection via transorbitalfrontal sinus approach in our department from Jan 2017 to Dec. 2017, were recorded and analyzed retrospectively. Of them, 2 were male and 4 were female, with an age range of 40 to 67 years (median age 54.5 years).ResultsThe tumors were located at the olfactory groove in 5 cases with involvement of the ethmoid sinus in one, while the other one was located at tuberculum and diaphragma sellae. The maximal diameters of the tumors were all within 4 cm. Simpson Grade II resection was achieved in 4 cases, and Simpson Grade I resection in the other 2. Cerebrospinal fluid rhinorrhea occurred in one patient. With continuous lumbar cistern drainage for 5 days, the cerebrospinal fluid rhinorrhea disappeared. All the patients got recovered uneventfully without complications such as fever or infection.ConclusionWith advantages of convenience, high efficiency, minimal invasion and few complications, the transorbitalfrontal sinus approach is especially suitable for the treatment of midline anterior cranial fossa meningiomas as the tumor blood supply originated from the dura mater of the anterior skull base can be processed at early stage.