Abstract: Cavernous sinuses are a pair of important sinuses located in the parasellar region which transmit the internal carotid artery and some brain nerves. Pituitary adenoma is a common intracranial tumor with a pretty high morbidity in the population. At present, the clinical treatment of pituitary adenoma invading the cavernous sinus is poorly effective. This article summarizes the progress in the treatment of pituitary adenoma invading the cavernous sinus, especially the applications of microscopic surgery and endoscopic surgery, as well as the progress of multidisciplinary and comprehensive treatment including drug treatment and radiotherapy. Future direction of the treatment for pituitary adenoma invading cavernous sinus is prospected.