Abstract: Skull base surgery is considered the most challenging and risky. The surgical skills of endoscopic endonasal skull base surgery are making unceasing progress, the surgical field is expanding continually, and the prospect for further development is quite remarkable. For now, the main constraining factors for the development of endoscopic endonasal skull base surgery in neurosurgery are the relatively long learning curve and the postoperative complications, including cerebrospinal fluid leakage and cranial nerve function damage. Therefore, reinforcing the endoscopic surgical training, being familiar with the endoscopic anatomy of the skull base, paying attention to the reconstruction of the skull base and the intraoperative neurophysiological monitoring, reducing the incidence of postoperative cerebrospinal fluid leakage and cranial nerve function damage, and stressing the importance of multidisciplinary cooperation in the treatment of cranial base tumors are all important measures for the further safe and effective development of endoscopic endonasal skull base surgery.