HPV感染与鼻内翻性乳头状瘤复发及恶变相关的Meta分析

Metaanalysis of association between human papilloma virus infection with recurrence and malignant transformation of sinonasal inverted papilloma

摘要:

 目的探讨人乳头状瘤病毒（HPV）与鼻腔鼻窦内翻性乳头状瘤（SNIP）发生、复发及恶变的关系。方法检索Pubmed、Web of science、 Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库，查找2000~2017年国内外公开发表的HPV与SNIP发生、复发及恶变相关的所有病例对照研究文献，应用RevMan 5.3统计软件对各研究原始数据进行统计分析。结果Meta分析示SNIP组HPV感染率明显高于对照组(P<0.01，OR=19.72，95%CI为7.91~49.18)；复发组HPV感染率明显高于对照组(P<0.01，OR=3.10，95%CI为1.90~5.08)；恶变组HPV感染率明显高于对照组（P<0.01，OR=2.09，95%CI为1.41~3.09）。结论HPV感染与SNIP的发生、复发及恶变密切相关。

关键词: ;人乳头状瘤病毒|鼻腔鼻窦内翻性乳头状瘤| 复发|恶变|Meta分析

Abstract:

 ObjectiveTo discuss the relationship between human papilloma virus (HPV) and recurrence as well as malignant transformation of sinonasal inverted papilloma (SNIP).MethodsPublished articles of casecontrol study about the relationship between HPV and recurrence as well as malignant transformation of SNIP were selected from Pubmed, Web of science, Embase, Cochrane Library, CNKI, VIP, Wanfang database and Chinese HowNet (2000—2017). All paper were reviewed and the original data were analyzed statistically by using RevMan5.3 statistical software.ResultsMeta analysis showed that HPV infection rate of the SNIP group was significantly higher than that of the control group (P<0.00001, OR=19.72, 95%CI=7.91~49.18), and those of the recurrence group, malignant transformation group were also significantly higher than that of the control group (P<0.00001, OR=3.10, 95%CI=1.90~5.08; P=0.0002, OR=2.09, 95%CI,=1.41~3.09), respectively.ConclusionHPV infection is closely related to the occurrence, recurrence as well as malignant transformation of SNIP.

Key words: ;Human papilloma virus| Sinonasal inverted papilloma| Recurrence| Malignant transformation| Meta analysis