Abstract:ObjectiveTo explore the significance of serum level of squamous cell carcinoma antigen (SCCAg) in preoperative diagnosis and postoperative followup of nasal inverted papilloma (NIP).MethodsClinical data of 37 patients with NIP and 45 with inflammatory diseases were analyzed retrospectively. The expression of serum SCCAg was detected in the patients of both groups before operation, and those of NIP group at 1 week and 3 months after operation. All the data were statistically analyzed.Results① The difference of preoperative serum SCCAg level between the NIP group and the inflammation group was statistically significant(P<0.001). ②The univariate analysis showed that preoperative SCCAg level in the NIP group was related to the pathological classification, the size of the tumors as well as their Kamel stages. ③The multivariate logistic regression analysis for identification of independent risk factors showed that pathological pattern was a predictor of SCCA elevation (P=0.025; odds ratio, 14.87). ④In the NIP group, the level of serum SCCAg one week after operation was significantly lower than the preoperative level(P<0.05), indicating the close relationship between SCCAg and NIP. However, the level of serum SCCAg at 3 months after operation got increased significantly compared with that of one week after operation (P<0.05), which suggested that SCCAg might be an index for postoperative followup of NIP.ConclusionBeing closely associated with NIP, SCCAg maybe an observational index for the diagnosis and prognosis of NIP.
