Abstract:Abstract:Precision medicine (PM) provides individual medical care according to unique genetic, biomarkers, environment and experience. Hearing loss (HL) is the most frequent sensorineural disease in the world, which is usually caused by single gene mutation. At present, the major therapeutic strategy of hearing loss relies on wearing hearing aid or implanting cochlear implant. However, the effect of this unpersonalized strategy varies from person to person. With the development of precision medicine tools such as next generation sequencing, hearing loss has become the optimal disorder to adopt strategies of precision medicine. The authors review current and future applications of precision medicine in hearing loss. Then, we propose a strategy that incorporates precision medicine of hearing loss into scientific research and clinical practices in the future, so as to improve the level of diagnosis and prognosis in the clinical practices and realize the objective of individual treatment finally. In the end, the ethical problems that may occur in the growing era of genomicsbased hearing loss treatment are discussed.
