头颈部多发副神经节瘤的诊疗分析和文献复习

Diagnosis and management of multiple paragangliomas of head and neck (A report of three cases and literature review)

摘要:

目的提高临床医生对头颈部多发副神经节瘤的认识及诊疗水平，减少误诊及漏诊。方法回顾性分析我院收治的3例头颈部多发副神经节瘤的临床资料，结合相关文献分析并总结其临床特点、影像学特点、诊疗经验及预后情况。结果3例患者临床表现均无特异性，影像学检查和病理诊断是主要诊断依据，均行手术治疗，术后未放、化疗。结论头颈部多发性副神经节瘤临床少见，易误诊、漏诊，临床表现及治疗方式的选择与肿物发生部位、大小、侵犯范围及分泌激素情况有关；影像学检查在本病的诊断、手术及随访中均起着至关重要的作用；治疗以手术为主；预后良好。

Abstract:

ObjectiveTo improve the diagnosis and treatment level of multiple paragangliomas of head and neck (MHNPGL) for reducing misdiagnosis or missed diagnosis of this disease.MethodsClinical data of 3 patients suffering from MHNPGL diagnosed and treated in our institution were analyzed retrospectively. The clinical features, radiological characteristics, diagnosis, treatment and prognosis of the patients were summarized with literature review.ResultsThe clinical manifestations of the 3 patients were nonspecific. Their diagnoses were confirmed mainly by imaging and pathologic examinations. All patients received surgical treatment without postoperative radiotherapy or chemotherapy.ConclusionsMHNPGL is rare in clinic and easy to be misdiagnosed or undiagnosed. The clinical manifestations and selection of treatment modality are tightly associated with the tumor's site, size, invasive activity as well as secretive condition. Imageology plays a vital role in the diagnosis, surgical treatment and followup of this tumor. Surgery is the main treatment method with good prognosis.