Abstract:ObjectiveTo study the clinical features, diagnosis and treatment of primary laryngeal amyloidosis.MethodsClinical data of 14 patients suffering from primary laryngeal amyloidosis were retrospectively analyzed. All the patients received surgical treatment in Beijing Tongren Hospital from April 2015 to April 2016. Of them, 2 were male and 12 were female. Their age ranged from 24 to 61 years old with an average of (47±10). The disease course ranged from 3 months to 15 years with an average of (3.7±4.3) years.ResultsCO2 laser removal of laryngeal amyloidosis with selfretaining laryngoscope under general anesthesia was performed to all patients. One patient with insignificant symptom improvement due to granulation tissue on bilateral ventricular bands received removal of granulation tissue under general anesthesia 9 days after the initial operation. Postoperative followup of 2 months to one year showed obvious relief of hoarseness. No recurrence occurred.ConclusionThe etiology of primary laryngeal amyloidosis is unknown. It occurs mainly in the middleaged. Ventricular bands, ventricles of larynx and vocal cords are the most frequent sites of origin. Hoarseness and dyspnea are the most common symptoms. Laryngoscopy usually shows nodular projection or diffuse submucosal mass. Surgical operation is the most important method for this disease, especially CO2 laserassisted laryngeal microsurgery. Positive Congo red staining and “applegreen” birefringence with polarized light are the most specific histopathological characteristics for the diagnosis of laryngeal amyloidosis.
