Abstract:ObjectiveTo observe the clinical effect of antihistamines for preventive treatment of seasonal allergic rhinitis in Shanghai Minhang district.MethodsA total of 89 outpatients with seasonal allergic rhinitis from Oct 2014 to Apr 2015 were recruited and randomly divided into preventive treatment group (n=44) and standard treatment group (n=45). For the patients of the preventive treatment group, oral administration of mizolastine (once a day with a daily dosage of 10 mg) started 2 weeks before the peak of fluttered pollen and lasted to the end of pollen season. As for the patients of the standard treatment group, oral administration of mizolastine (once a day with a daily dosage of 10 mg) started once they came to clinic during the peak of fluttered pollen and lasted to the end of pollen season. Treatment effect of both groups was recorded every two weeks by visual analog scale (VAS) and the medical outcomes study 36 items short form health survey (SF36).ResultsAnalyses of VAS scores showed that the score improvements of nasal itching, nasal congestion, sleep, impact on work and holistic comfort in the preventive treatment group were better than those of the standard group(all P<0.01). As for the patients' condition improvement in the aspects of SF36, the preventive treatment group was better than the standard group on two dimensions of RP and RE. The patients of the preventive treatment group could maintain better quality of life throughout the peak of fluttered pollen.ConclusionPreventive and persistent medication can obviously inhibit seasonal allergic rhinitis in Shanghai Minhang district.
