Abstract:Allergic rhinitis（AR) is an allergic nasal disease, due to multiple gene regulation and more closely related to environmental factors. PM2.5 is recognized as a health hazard of serious pollutants in the atmospheric environment. Nasal cavity, which is the first portal of respiratory defense, exposes firstly to PM2.5, and adsorbs PM2.5 to aggregative response. PM2.5 may play an important role in the pathogenesis of allergic rhinitis. PM2.5 attracts more and more attention these years due to its important roles in the epidemiological effect of AR. Exploratory studies of mechanism between PM2.5 and AR had been performed. Exposure to PM2.5 induced the oxidative stress reaction and expression of inflammatory cytokines, which contribute to the impairment of nasal epithelial barrier function. Gene methylation regulation may play essential roles on the relationship between PM2.5 and AR. To further study the effect of PM2.5 on AR can provide a new perspective of comprehensive prevention and control strategy of AR.MethodsResultsConclusion
