ObjectiveTo compare the clinical effect for nasal vestibule cyst between endoscopic surgery with power cutter system and lowtemperature plasma ablation.Methods44 patients suffering from nasal vestibular cyst hospitalized in our department during June 2010 to March 2015 were randomly divided into two groups with equal number. The patients in one group received endoscopic surgery with power cutter system (uncovery group), and lowtemperature plasma ablation was applied to those in the other group (plasma group). The clinical effect between the two groups was compared.ResultsCompared with the uncovery group, the mean operation time, average volume of bleeding and wound healing time of the plasma group were lower with less postoperative pain and facial swelling. The differences were all statistically significant (all P<0.05).ConclusionWith advantages of good clinical effect and high safety, endoscopic resection of nasal vestibular cyst with lowtemperature plasma is worthwhile for promotion.