CRISPR/Cas靶向编辑技术在遗传性耳聋研究中的应用前景

The application of CRISPRCas system in studying hearing loss

摘要:

摘要耳聋是一种常见的公共健康问题，对人类经济和社会造成极大的损失，60%以上的感音神经性聋由遗传因素导致，遗传性耳聋研究一直是研究领域的热点，本文针对新型CRISPR/Cas靶向编辑技术的研究现状，阐述该技术对遗传性耳聋研究的价值，并探讨其未来的应用前景。

关键词:基因编辑|聋|遗传性疾病|CRISPR/Cas

Abstract:

AbstractHearing loss is one of the most common publichealth issue that causes great damage to human economy and society. As estimated, up to 60 percent of prelingual hearing loss is attributable to genetic factors. Hereditary hearing loss is always a hot field of genetic disorders research. In this paper, we describe CRISPR/Cas system currently used for genome editing, and discuss issues pertaining to applications of CRISPR/Cas9 in auditory systems implicated in genetic hearing loss.

Key words:Genome editing| Deafness|Hereditary hearing loss|CRISPR/Cas