鼻腔RosaiDorfman病2例报道并文献复习

Rhinosinusal RosaiDorfman disease:A report of 2 cases and literature review

摘要:

目的探讨鼻腔鼻窦结外RosaiDorfman病的病因、病理、临床表现、诊断及治疗。方法报道2例鼻腔RosaiDorfman病的临床资料并结合相关文献复习。结果鼻腔鼻窦结外RosaiDorfman病缺乏特异性的临床特征，易导致误诊。病理显示不同形态的组织细胞增生，其内见吞噬的淋巴细胞、浆细胞及中性粒细胞。免疫组化提示CD68(++),S100蛋白（+），Cdla(-)。结论鼻腔鼻窦结外RosaiDorfman病是一种组织细胞增生性疾病，诊断主要依靠病理学组织检查，目前无系统规范的治疗方法，局部手术切除及激素治疗效果尚佳，但远期效果有待进一步观察。

Abstract:

Abstract:ObjectiveTo evaluate the etiological factors, pathological features, clinical manifestations, diagnosis and treatment of RosaiDorfman disease(RDD) in nasal cavity and paranasal sinus.MethodsClinical and pathological data of 2 cases with rhinosinusal RDD were analyzed retrospectively, and the pertinent literature was reviewed.ResultsWithout specific clinical features, rhinosinusal RDD could be misdiagnosed easily. Pathology revealed different morphologies of cell proliferation with engulfed lymphocytes, plasma cells and neutrophils. Immunohistochemical staining showed CD68 (++), S100 (+), Cdla (-).ConclusionRhinosinusal RDD is a（kind of） proliferative histiocytic disorder. Its diagnosis depends mainly on biopsy. As for the treatment of this disease, the strategies are not systemic and standard. The therapeutic effects of local resection and hormonotherapy are fairish. However, the longterm effect need to be further observed.