鼻咽部淀粉样变性病的诊治分析

Analysis of the diagnosis and treatment of nasopharyngeal amyloidosis

摘要:

目的 探讨鼻咽部淀粉样变性病的发病机制、分类、诊断及治疗。方法 通过MRI、腹壁脂肪活检及病理学检查确诊的1例鼻咽淀粉样变性病患者，全麻鼻内镜下切除病变并结合文献进行分析。结果结合影像学资料经鼻内镜下完整切除病变，术后病检示黏膜下见大量无定型样物质，刚果红染色（++），术后随访1年无复发。结论鼻咽部淀粉样变性病需病理切片确诊，MRI是诊断与鉴别诊断该病的最佳辅助检查，其首选治疗方式为鼻内镜下手术切除。

Abstract:

ObjectiveTo discuss the categorization, pathogenesis, diagnosis, and treatment of nasopharyngeal amyloidosis.MethodsThe case diagnosis of nasopharyngeal amyloidosis was confirmd by nasopharyngeal biopsy by MRI and the biopsy of abdominal wall fat. The nasopharyngeal lesion was resected endoscopically. The referred literature was reviewed.ResultsNasopharyngeal amyloidosis was diagnosed via preoperative and postoperative pathological examinations.MRI might be helpful for the diagnosis and differential diagnosis. The nasopharyngeal lesion was resected endoscopically. Pathological examination displayed amorphous pink material with positive Congored staining. The patient has been followed up for one year postoperatively without recurrence.ConclusionsThe diagnosis of nasopharyngeal amyloidosis depends on pathological examination. MRI is the best auxiliary examination for the differential diagnosis, and surgical resection via endoscopic approach is the preferred treatment.