星形胶质细胞上调基因-1蛋白在鼻咽癌中的表达及临床意义

Expression of AEG-1 protein in nasopharyngealcarcinoma and its clinical significance

摘要:

目的 探讨星形胶质细胞上调基因-1（astrocyte elevated gene1，AEG-1）蛋白在鼻咽癌中的表达及其临床意义。方法 采用Western blotting技术检测AEG-1蛋白在4株鼻咽癌细胞株、47例鼻咽癌组织及21例鼻咽部黏膜中的表达。结果 AEG-1蛋白在鼻咽癌细胞和组织中的表达较鼻咽部黏膜均显著上调，其表达水平与患者血清EB病毒滴度的高低（P=0.046）、T分级（P=0.001）、临床分期（P=0.001）、颈部淋巴结转移（P=0.010）呈显著正相关。结论 AEG-1蛋白可能在鼻咽癌的发生发展中起重要作用。

Abstract:

Objective To investigate the expression of AEG1 protein and its clinical significance in nasopharyngeal carcinoma (NPC). Methods Western blot was used for detecting the expression of AEG1 protein in 4 NPC cell lines, 21 specimens of normal nasopharyngeal epithelium and 47 of NPC. Results The expression level of AEG1 protein was significantly upregulated in both NPC cell lines and NPC specimens. Moreover, the expression of AEG1 protein was positively correlated to EB virus infection (P=0.046), T stage (P=0.001), clinical stage (P=0.001) and cervical lymph node metastasis (P=0.010). Conclusion AEG-1 protein may play a significant role in the initiation and progression of NPC.