垂体肿瘤转移基因在喉鳞状细胞癌中的表达及临床意义

Expression of PTTG in laryngeal squamous cellcarcinoma and its clinical significance

摘要:

摘要：目的 探讨喉鳞状细胞癌中垂体肿瘤转移基因（pituitary tumor transforming gene，PTTG）蛋白表达及其临床意义。方法 采用免疫组织化学SP法检测56例喉鳞癌及13例喉正常黏膜中PTTG的表达，分析PTTG表达与喉鳞癌临床病理指标之间的关系。结果 PTTG蛋白在喉鳞癌组织中的阳性表达率为64.3%，在喉正常黏膜细胞中的阳性表达率为23.1%（P<0.05）；PTTG的阳性表达及其强度与喉鳞癌临床病理指标之间差异具有统计学意义（P<0.05）。结论 PTTG基因蛋白阳性表达及其强度可做为判定喉鳞癌生物学行为及其预后的参考指标之一。

Abstract:

Objective To study the expression of pituitary tumor transforming gene (PTTG) in laryngeal squamous cell carcinoma (LSCC) and its clinical significance. Methods The expression of PTTG was detected with immunohistochemical SP method in 56 samples of LSCC and 13 of normal laryngeal mucosa. The relationship of expression of PTTG with the biological behaviors of LSCC was analyzed. Results The positive rates of PTTG were 64.3% and 23.1%in LSCC and normal laryngeal mucosa (P<0.05). The positive rate and the strength of expression of PTTG were statistically related with the biological behaviors of LSCC. Conclusion The expression of PTTG and its strength may become important targets in determining the biological behaviors and the prognosis for LSCC.