Abstract:Objective To compare the currative effect in clinical outcome between the coblation thyroidectomy (CT) and conventional open thyroidectomy (COT) in treatment of thyroid adenoma, and to explore the feasibility and efficacy of CT. Methods From July 2008 to December 2009, 72 patients with thyroid adenoma were randomly divided into two groups. CT was performed in one group and COT in the other group. The intraoperative blood loss, postoperative pain and shortterm outcome were compared between the two groups. Results All planning operations were successfully performed. No recurrences have been observed till now. The intraoperative blood loss in CT group was apparently less than that in COT group (P<0.05). The pain in the first postoperative day in COT group was more serious than that in CT group (P<0.05). The rate of swallowing discomfort happened in COT group was more than that in CT group (P<0.05). And the patients in CT group were more satisfied with the cosmetic outcome than those in COT group (P<0.05). Conclusion In dealing with thyroid adenoma, CT is feasible and safe with ideal minimally invasive outcome.