SHIP2在喉鳞状细胞癌中的表达及意义

Expression of SHIP2 protein in laryngeal squamous cellcarcinoma and its clinical significance

摘要:

摘〓要：〓目的〓〖HT5”SS〗探讨含SH2结构域的Ⅱ型5’肌醇磷酸酶2（SH2 domain containing 5’inositol phosphatase2, SHIP2）蛋白在喉鳞状细胞癌（喉鳞癌）组织中的表达及与临床病理特征和预后的关系。〖HTH〗方法〓〖HTSS〗应用免疫组织化学技术检测SHIP2蛋白在54例喉鳞癌组织及16例喉癌旁黏膜组织中的表达。〖HTH〗结果〓〖HTSS〗SHIP2蛋白在喉鳞癌组织中表达显著升高，其表达与喉鳞癌T分期、临床分期、转移及复发密切相关（P<0.05）；生存分析表明SHIP2高表达组与低表达组患者5年无瘤生存率分别为19.2%和64.3%，5年总生存率分别为26.9%和85.7%，两组差异均有统计学意义（P<0.05）。多因素分析示SHIP2表达水平为喉鳞癌预后的独立影响因素。〖HTH〗结论〓〖HTSS〗SHIP2蛋白可能在喉鳞癌的发生、发展中发挥了重要作用，且具有预后评估价值。  

Abstract:

Abstract: Objective To investigate the expression of SHIP2 protein in laryngeal squamous cell carcinoma (LSCC) and its clinical significance. Methods Immunohistochemistry was performed on paraffinembedded tissue specimens to investigate SHIP2 protein expression, which included 54 specimens of LSCC and 16 adjcent tissue samples. Results The significantly increased SHIP2 protein expression was identified in both LSCC tissue and cell lines and the overexpresion was tightly associated with LSCC T classification, clinical stage, metastasis and recurrence (P<0.05). The diseasefree survival and overall survival rates of patients with SHIP2 overexpression were lower than those with low SHIP2 expression (19.2% vs 64.3%, P<0.05; 26.9% vs 85.7%, P<0.05). Multivariate analysis revealed that the expression of SHIP2 was an independent prognostic factor for patients with LSCC. Conclusion SHIP2 might play a critical role in the initiation and progression of LSCC, and might be a valuable prognostic marker of the tumor.