盐酸氮卓斯汀鼻喷剂治疗变应性鼻炎的临床疗效分析

Clinical efficiency of Azelastine sprayin the treatment of allergic rhinitis

摘要:

摘 要： 目的 观察盐酸氮卓斯汀鼻喷剂治疗变应性鼻炎（allergic rhinitis, AR）的临床疗 效。 方法 对235例变应性鼻炎患者应用盐酸氮卓斯汀鼻喷剂治疗2个月，每天2次 （0.56 mg/d），每次每鼻孔1喷，应用2周及2个月后评价其临床疗效。 结果 轻度间歇性AR、中重度间歇性AR 、轻度持续性AR和中重度持续性AR应用盐酸氮卓斯汀鼻喷剂治疗前后其临床症状（包括打喷嚏、流清涕、鼻塞、鼻痒等）和体征不同记分例数比较差异有统计学意义 （P<0.01）；治疗2周及2个月后显效率分别为56.4%，55.3%；有效率分别为30.9%， 31.7%；无效率为12.7%，13%。 结论 盐酸氮卓斯汀鼻喷剂能有效缓解变应性鼻炎患者由组织胺和炎症细胞及其介质所引起的相关临床症状，治疗上是有效和安全的。

关键词:

盐酸氮卓斯汀|鼻炎|变应性|临床疗效

Abstract:

Abstract: Objective To assess the clinical efficiency of Azelastine spray in the treatment of allergic rhinitis (AR). Methods Azelastine spray was applied to 235 patients with AR and the efficiency was separately assessed two weeks and two months after first application. Results The differences of total symptom scores before and after Azelastine treatment in patients with mild intermittent, middlesevere intermittent, mild perennial and middlesevere perennial AR were statistically significant (P<0.01). The effective rates in above groups were 95.9%, 80.7%, 95.1% and 77.9% respectively. Conclusion Azelastine spray can effectively relief the symptoms caused by Histamine and inflammatory cells and their mediators. Azelastine spray is effective and safe in the treatment of AR.

Key words:

Azelastine| Rhinitis|allergic|Clinical efficiency