CXCR4在鼻面部基底细胞癌中的表达及临床意义

Expression of CXCR4 in basal cell carcinoma of nasal surface and the significance in surgical margins

摘要:

摘要：目的 探讨CXCR4在鼻面部基底细胞癌、癌组织手术切缘及癌旁正常皮肤组织中的表达及临床意义。方法 通过免疫组织化学方法检测60例基底细胞癌组织、手术切缘及30例癌旁正常组织中CXCR4的表达。结果 CXCR4在鼻面部基底细胞癌组织中的阳性表达率为80%（48/60），在病理学为阴性的手术切缘中的阳性表达率为33%（20/60），癌旁正常组织中的阳性表达率为10%（3/30），3组之间有统计学意义（P<0.05）。CXCR4的表达与肿瘤的病理类型有关，而与年龄、性别及肿瘤的大小无关。结论 CXCR4在鼻面部基底细胞癌中呈高表达，其表达的程度与病理类型有关，并可作为预测肿瘤安全切缘的分子标记物。 

Abstract:

Abstract: Objective To discuss the expression of CXCR4 in specimens of nasalsurface basal cell carcinoma, surgical margintissue, and normal skin, then to explore its possible role in the surgical margins of basal cell carcinoma of nasal surface. Methods Specimens of 60 basal cell carcinoma and 30 pieces of normal skin of nasal surface were collected from Jan 2007 to Jan 2009. Immunohistochemical technique (SP) and image analysis were used for detecting the expression of CXCR4 in specimens of pathological negative margin, primary site of carcinoma and normal skin. And its relations to clinicopathological parameters were also analyzed.Results The expression rates of CXCR4 in primary site of carcinoma, pathological negative margin and normal skin were 80.0% (48/60), 33.3% (20/60) and 10.0% (3/30) respectively. The differences of the expression rates between each group were statistically significant (P<0.05). There was a significant correlation between the expression of CXCR4 and the pathological categories (P=0.017). No significant correlation was found between the expression of CXCR4 and age, sex and tumor size. Conclusion The expression of CXCR4 in basal cell carcinoma of nasal surface, surgical margins and normal skin is different. The CXCR4 may play an increasingly important role in establishing surgical margins, which may guide the surgical treatment for this tumor.