Abstract:OBJECTIVE:To investigate the methodology and effectiveness of free anterolateral thigh flap (ALT) for repairing large fullthickness defect of cheek after tumor resection. METHODS:From Dec 2006 to Dec 2009, large fullthickness defect of cheek after tumor resection was repaired with ALT in 19 patients. The defect size of jowl area ranged from 8 cm×6 cm to 4 cm×4 cm while that of cheek area was from 9 cm×7 cm to 6 cm×5 cm. The ALT was harvested with available size ranged from 20 cm×8 cm to 12 cm×6 cm. RESULTS:Flaps survived in all 19 cases with satisfactory vocal function and appearance. CONCLUSION:Owing to application of enough tissue and preservation of well appearance and function, ALT flap is ideal for repairing the large fullthickness defect of cheek after tumor resection.